{"id":4359,"date":"2025-04-29T22:31:46","date_gmt":"2025-04-29T22:31:46","guid":{"rendered":"https:\/\/friscotimes.org\/?p=4359"},"modified":"2025-04-29T22:31:46","modified_gmt":"2025-04-29T22:31:46","slug":"what-we-know-about-phthalates-in-plastic-and-heart-disease","status":"publish","type":"post","link":"https:\/\/friscotimes.org\/?p=4359","title":{"rendered":"What We Know About Phthalates in Plastic and Heart Disease"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-2fd7d53c\"><span>The Latest<\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">The news made for an alarming headline this week: Research showed that common chemicals in plastics were associated with 350,000 heart disease deaths across the world in 2018.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The statistic came from a study <a class=\"css-yywogo\" href=\"https:\/\/www.thelancet.com\/journals\/ebiom\/article\/PIIS2352-3964(25)00174-4\/fulltext\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">published Monday in the journal eBioMedicine<\/a>. The authors, a group of researchers at New York University\u2019s Grossman School of Medicine, estimated that roughly 13 percent of cardiovascular deaths among 55- to 64-year-olds worldwide that year could be attributed to phthalates, which are used in food packaging, shampoo, toys and more.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Research on the effect of phthalates on cardiovascular disease is still emerging, but their link to metabolic risk factors like obesity suggest they could play a role in heart disease.<\/p>\n<p class=\"css-at9mc1 evys1bk0\"> While experts agree that phthalates are harmful, they cautioned that the study relied on complex statistical modeling and a series of assumptions and estimates that make it difficult to determine how many deaths might be linked to the chemicals.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cThis is an early step of trying to understand the magnitude of the problem,\u201d said Dr. Mark Huffman, a cardiologist and a co-director of the global health center at WashU Medicine in St. Louis. But, he added, there\u2019s a need for far more studies to understand the relationship between phthalates and heart health, and what other factors might come into play.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-7101f615\"><span>The Background<\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">Phthalates are found in personal care products like shampoos and lotions, as well as in food containers and packaging. It\u2019s possible to ingest them through food, absorb them through the skin from products containing them or breathe them in as dust.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Studies have shown that phthalates are endocrine disrupters, meaning that they can interfere with our hormones. They have been associated with negative effects on reproductive health, pregnancy and birth issues.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Some studies have shown an association between phthalates and cardiovascular disease, but there isn\u2019t strong evidence to show that the chemicals directly cause heart issues, said Sung Kyun Park, a professor of epidemiology and environmental sciences at the University of Michigan School of Public Health.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">There is evidence that phthalates increase the risk of metabolic disorders like obesity and Type 2 diabetes, which can cause cardiovascular disease.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">One way phthalates may do this is by increasing oxidative stress \u2014 cell and tissue damage that happens when there are too many unstable molecules in the body \u2014 and by promoting inflammation, said Dr. Leonardo Trasande, senior author of the new paper and a professor of pediatrics and population health at N.Y.U.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-58147e68\"><span><strong class=\"css-8qgvsz ebyp5n10\">The Research<\/strong><\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">In the latest study, researchers attempted to quantify global cardiovascular deaths attributable specifically to one type of phthalate, known as DEHP. One of the most widely used and studied phthalates, DEHP is found in vinyl products including tablecloths, shower curtains and flooring.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The researchers relied on estimates from previous research for several measures: phthalate exposures, the risk of such exposures on cardiovascular deaths and the global burden of cardiovascular disease. They then calculated the share of deaths attributable to phthalate exposures in different countries, Dr. Trasande said. The Middle East, South Asia, East Asia and the Pacific accounted for nearly three-quarters of these deaths.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-51d75a7c\"><span>The Limitations<\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">This was an observational study that showed a correlation between estimated exposure to the chemical and disease at the population level. Experts said that the methods used were not unusual for studies that model global disease, but that such studies come with caveats.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">For example, Dr. Huffman said, the estimates from the literature that the authors relied on in their calculations may themselves have incorporated some bias or confounding variables, such as socioeconomic status or dietary behaviors, that could relate both to plastic exposure and to cardiovascular disease rates.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cA pretty important part of the result of the model is what you put into the model,\u201d Dr. Huffman said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The study also relied on an earlier analysis by Dr. Trasande to estimate the risk of cardiovascular death from phthalate exposure, after controlling for other known risk factors. But <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34654571\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">that paper<\/a> only examined U.S. patients, which means it might not be possible to generalize the results to a global population, where dietary habits, cigarette smoke exposure, physical activity and other cardiovascular risk factors may vary.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-b30f02b\"><span><strong class=\"css-8qgvsz ebyp5n10\">What\u2019s Next<\/strong><\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">What\u2019s clear from the study, experts said, is that we need more research on phthalate exposure and the associated health risks. Though it would be ethically impossible and impractical to do a classic randomized trial, in which one group of people were exposed to phthalates and others were not and they were followed for many years, other types of studies could help more clearly establish a link.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">One way, Dr. Park said, would be to have researchers recruit a large, representative sample of patients, measure their levels of exposure and follow them for years, perhaps until death. Dr. Huffman suggested it would also be worthwhile to try out strategies that might reduce exposure levels and then measure any changes in health outcomes.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Tracey Woodruff, director of the program on reproductive health and the environment at the University of California, San Francisco, said that despite the uncertainties in the estimates of the current paper, it is clear that phthalates can increase the risks of preterm birth, reproductive issues and metabolic disorders. To her, the findings only add to the list of reasons to reduce the amount of phthalates in the supply chain.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>The Latest The news made for an alarming headline this week: Research showed that common chemicals in plastics were associated with 350,000 heart disease deaths across the world in 2018.&hellip;<\/p>\n","protected":false},"author":632,"featured_media":4360,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[5613,5615,4,5616,5614,5612,4603],"tags":[],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - 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